Pain ReliefThe treatment of pain both in its acute and chronic forms remains a significant clinical challenge. Many intricate and overlapping physiological systems contribute to pain states and there are numerous pathways identified as possible targets for intervention. Chromocell, with its ability to rapidly create multiple complex cell lines has drug discovery programs in the pain area covering both voltage gated and ligand gated ion channels. These targets are members of large families of related proteins. Panels of cell lines allow for the discovery of compounds with either broad activity across a class of receptors or specific activity at a particular subunit. Chromovert technology has allowed the creation of cell lines to access drug targets comprising not only the pore forming subunit but also regulatory subunits critical for physiological activity. Working with cell lines that express all subunits of the drug target is crucial for successful drug discovery. To date, discovery efforts were limited to working with suboptimal cell lines not expressing all the pertinent subunits. Chromovert technology enhances the chances of finding effective compounds, as we are screening the targets in their complete form. Hit compounds from these enhanced screens are advanced through lead optimization to clinical trials.
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