Anxiety TreatmentAnxiety disorders and their associated symptoms cause a loss of $42 billion to the U.S. economy each year. Current therapeutics for anxiety have many unwanted side effects including sedation. Chromocell has a drug discovery program for improved anxiety treatment. We created a panel of cell lines expressing related receptors involved in anxiety and cognition. This approach powerfully demonstrates the value of Chromovert technology in that the panel can be used to screen for compounds with specificity for a subset of receptors with the desired activity at closely related receptors. Such a combinatorial panel of cell lines makes it possible to discover and develop new therapeutics against complex heteromultimeric targets. Compounds identified with the optimal activity at related targets enter lead optimization and clinical trials. In a related approach, different genetic versions of a single gene can be expressed to identify patients who are likely to respond. This approach clarifies clinical trial results and reduces expenses.
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